What is the difference between the Waterproof Mattress Protector and Organic Mattress Pad? January 15, 2021 15:01 Updated The Waterproof Mattress Protector uses this polyurethane layer to provide waterproof protection. The Organic Mattress Pad is 100% organic and provides natural protection against spills and stains without the use of polyurethane materials. Related articles Can I wash the mattress protector? Does the mattress protector sleep hot? What is a mattress pad and how is it used? How does the mattress protector fit on my mattress? How long will the mattress pad last?