What is the difference between the Waterproof Mattress Protector and Organic Mattress Pad? January 31, 2024 21:32 Updated The Waterproof Mattress Protector uses this polyurethane layer to provide waterproof protection. The Organic Mattress Pad is organic and provides natural protection against spills and stains without the use of polyurethane materials. Related articles Can I wash the mattress protector? How does the mattress protector fit on my mattress? Does the mattress protector sleep hot? What is a mattress pad and how is it used? How long will the mattress pad last?