How long will my mattress protector last? January 15, 2021 14:56 Updated With normal use and regular washing the mattress protector can provide durable protection for five years or longer. Related articles Can I wash the mattress protector? How does the mattress protector work with my fitted sheet and other toppers? What is the difference between the Waterproof Mattress Protector and Organic Mattress Pad? Is the mattress pad waterproof? What is a mattress pad and how is it used?